Enoxaparin Sodium Injection, USP

Welcome! Now that you have been discharged from the hospital, your doctor has prescribed Enoxaparin Sodium Injection, USP for you to inject at home while you recover. You may be at increased risk for developing deep vein thrombosis (DVT) blood clots, a serious health condition for a period of time after you leave the hospital, so it's very important to continue the injections at home as prescribed by your doctor. 

Learn more about DVT

Teva - enoxaparin - Sodium Injection, USP

How to give Self-Injections of Enoxaparin Sodium Injection, for at-home DVT prevention

Proper training in subcutaneous injection technique should be provided by a healthcare professional. For general instructions on giving self-injection of Enoxaparin Sodium Injection, review the self-injection instructions. Be sure to follow specific instructions provided by your healthcare provider.

Approved Uses

Enoxaparin sodium injection is a prescription medicine used to:

  • Reduce the risk of blood clots that may develop with abdominal, hip, or knee surgery, or as a result of limited movement ability during an acute illness.

  • Treat blood clots that may be formed in a deep vein, known as deep vein thrombosis (DVT) that usually occurs in the legs.

Important Safety Information

People who take a blood thinner medicine (anticoagulant) like enoxaparin sodium injection, and have medicine injected into their spinal and epidural area, or have a spinal puncture, have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:

  • A thin tube called an epidural catheter is placed in your back to give you certain medicine.

  • You take non-steroidal anti-inflammatory drugs (NSAIDs) or a medicine to prevent blood from clotting.

  • You have a history of difficult or repeated epidural or spinal punctures.

  • You have a history of problems with your spine or have had surgery on your spine.

If you take enoxaparin sodium injection and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots. Tell your doctor right away if you have back pain, tingling, numbness, muscle weakness (especially in your legs and feet), or loss of control of the bowels or bladder (incontinence).

Do not take enoxaparin sodium injection if you are bleeding; have low platelet counts (thrombocytopenia); or have had an allergic reaction (such as itching, hives, or difficulty breathing) to enoxaparin, heparin, or pork products.

Enoxaparin sodium injection may cause excessive bleeding, which can be serious and, in some cases, life-threatening. People who have recently had certain medical procedures, or have uncontrolled high blood pressure, stomach ulcers, diabetes with vision problems, or kidney problems may have an increased risk of bleeding.

Call your doctor or get medical help right away if you develop any of these signs or symptoms of bleeding:

Unexpected bleeding or bleeding that lasts a long time, such as:

  • Nosebleeds that happen often

  • Unusual bleeding from gums

  • Menstrual bleeding that is heavier than normal, or vaginal bleeding
  • Bleeding that is severe or that you cannot control

  • Red, pink, or brown urine

  • Bright red or black stools (looks like tar)

  • Cough up blood or blood clots

  • Vomit blood or your vomit looks like "coffee grounds"

  • Headaches, feeling dizzy or weak

  • Pain, swelling, or new drainage at wound sites

While taking enoxaparin sodium injection you may bruise more easily and it may take longer for bleeding to stop. These may be symptoms of low platelet counts. Tell your doctor right away if you have any bruising, a rash or dark red spots under the skin, or feel unusually tired while taking enoxaparin sodium injection. 

Enoxaparin sodium injection may increase your risk of bleeding if used while taking other medicines that may increase your risk of bleeding, such as warfarin, aspirin, ibuprofen and NSAIDs, or clopidogrel and other medicines used to prevent or treat blood clots. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, such as aspirin or other NSAIDs. 

Tell all of your doctors and dentists that you are taking enoxaparin sodium injection. They should talk to the doctor who prescribed enoxaparin sodium injection for you before you have any surgery, medical or dental procedure. In an emergency, have family members tell emergency room staff that you are taking enoxaparin.

Take enoxaparin sodium injection exactly as prescribed by your doctor. Do not stop taking enoxaparin sodium injection without talking to your doctor. Enoxaparin sodium injection should not be substituted with other heparin or blood thinner medicines.

Enoxaparin sodium injection may cause side effects at the site of injection, including mild skin irritation, redness, and bruising. The most common side effects of enoxaparin sodium injection include bleeding, anemia, a drop in platelet counts, increased liver enzymes, diarrhea, and nausea, skin discoloration due to bleeding underneath, fever, swelling, shortness of breath, confusion, and injection site pain. 

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of enoxaparin sodium injection. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed Warning.